HOTAIR is one of the most studied lncRNAs that is overexpressed in several cancers including CC, and is known by its role in modulating chromatin state by scaffolding the three components of the chromatin-modifying complex PRC2: EZH2, SUZ12, and embryonic ectoderm development (EED) and directs them to distant targeted loci, which consequently induces the H3K27 tri-methylation on promoters of specific genes (16)(85). Through a similar mechanism, HOTAIR appears to regulate the Wnt/β-catenin pathway as well. This evidence concerns the gene HOTAIR and cancer.