IL12RB2 and connective tissue disorder: Patient-related factors include advanced age, female sex, surgeries at the site of radiotherapy, smoking, immunocompromised and poor nutritional status, higher body mass index (BMI), fair complexion, genetic factors such as the presence of IL12RB2 and ABCA1 genes, history of photosensitivity, diabetes, preexisting connective tissue disorder, and infections such as HIV [8,9].