Accumulating evidence indicates that elevated FGF21 concentrations are associated with a higher incidence of diabetes, chronic kidney disease, hypertension, and cardiovascular diseases, including coronary artery disease, heart failure, atrial fibrillation and AMI (Gu et al., 2021; Shen et al., 2017; Shen et al., 2018; Wang et al., 2015; Wu et al., 2018; Zhang et al., 2015). This evidence concerns the gene FGF21 and heart failure.