We also found that troponin I (HR: 6.842, 95% CI [3.870–12.094]), NT-proBNP levels (HR:3.452, 95% CI [1.765–6.750]), and mitral regurgitation (HR: 2.011, 95% CI [1.160–3.489]) increased the risk of MACEs. The gene discussed is NPPB; the disease is Mitral regurgitation.