In this in silico study using 3 bioinformatics algorithms, including miRDB (http://mirdb.org/), TargetScan (http://www.targetscan.org/vert_72/), and miRmap (https://mirmap.ezlab.org/app/), we found that MDM2, which was proved to be involved in BC progression,13 may be a potential target of miR-16-1-3p (Figures 6A and 6B). Here, MDM2 is linked to breast cancer.