It is widely accepted that an overactive immune response can have serious consequences in COVID-19 patients, such as an autoimmune response and/or cytokine storm, which could be prevented by regulating BCR signaling by increasing the expression levels of coinhibitory receptors.41 We found that MSCs were proficient at modulating B-cell activation to a level sufficient to combat COVID-19 by upregulating both costimulatory and coinhibitory receptors in patients’ B cells, which has not been demonstrated by other immunomodulatory therapies. The gene discussed is BCR; the disease is COVID-19.