Using pCLE, we found that the normal mucosa showed round pits and round openings, the pyloric glands showed continuous short rod-shaped pits with slit-like openings, while the inflammatory gastric mucosa showed regular pits with increased fluorescein signal in the stromal compartment; atrophic gastric mucosa showed reduced pits with dilated openings, and the appearance of goblet cells with dark mucin was a typical feature of gastritis associated with intestinal metaplasia. The gene discussed is MUC5AC; the disease is gastritis.