Notably, while CDH13 (encoding T-cadherin, a GPI-anchored protein with cell adhesion properties that is highly expressed in the brain and cardiovascular system) has been possibly associated with ADHD through GWAS with no causative or functional proof43–45, to date cadherins have not been implicated in the pathophysiology of ADHD46. This evidence concerns the gene CDH13 and attention deficit-hyperactivity disorder.