TIPE2 and infectious otitis media: We found that the total tumor number of AOM/DSS-induced CRC from Tipe2+/+ mice was higher than that from Tipe2-/- (Fig. 5B), especially in tumors with greater diameter more than 2 mm (Fig. 5C), suggesting that the occurrence of AOM/DSS-induced CRC in Tipe2+/+ mice was probably earlier than that in Tipe2-/- mice.