ABHD5 and hydrops fetalis: Moreover, excessive TG accumulation was associated with the upregulation of ER stress markers, ROS production, mitochondrial impairment, ATP reductions, and cardiac remodeling and dysfunction in CGI-58cko mice (Figs. 2 and 4–6), whereas inhibition of ER stress by 4-PBA significantly reversed these effects in CGI-58-knockdown NRCMs (Fig. 6) or in CGI-58cko mice (Fig. 7), confirming that ER stress activation was the most important mechanism for CGI-58-deficiency-induced HF.