Recently, Zhuo et al. [60] demonstrated that TNF-α/NF-κB/JMJD2D signalling protects against DSS- or azoxymethane and DSS (AOM-DSS)/DSS-induced colitis via activation of Hh/Gli1/Gli2 and Wnt/β-catenin signalling. This evidence concerns the gene KDM4D and colitis.