NPC1L1 and coronary artery disorder: “LDL [low density lipoprotein] cholesterol lowering alleles at the NPC1L1 locus were inversely associated with coronary artery disease (OR [odds ratio] for a genetically predicted 1-mmol/L [38.7-mg/dL] reduction in LDL-C of 0.61 [95% CI, 0.42-0.88]; P=.008) and directly associated with type 2 diabetes, both individually and collectively (OR for a genetically predicted 1-mmol/L reduction in LDL-C of 2.42 [95% CI, 1.70-3.43], P<.001; estimated absolute risk difference, 5.3 incident cases per 1000 person-years for a 1-mmol/L genetically predicted reduction in LDL-C).”97