Moreover, WNT5A ligand co-receptors – ROR1 and ROR2 – have been already described in melanoma as key factors driving invasion in vitro and in vivo (Fernández et al., 2016; Lai et al., 2012; O’Connell et al., 2013; O’Connell et al., 2010). Here, ROR2 is linked to melanoma.