RNF43 and melanoma: Lower proliferation of RNF43/ZNRF3 dKO cells can be caused by senescence because these cells have elevated WNT5A pathway activity (i.e., Figures 3B and 4I, Figure 4—figure supplement 1E and F) and WNT5A at the same time causes a senescence-like phenotype of melanoma after exposition to vemurafenib (Webster et al., 2015).