WNT5A and melanoma: The importance of WNT5A-driven signaling in melanoma is thus well recognized, and melanoma represents probably the most characterized (and most clinically relevant) pathophysiological condition where noncanonical WNT5A signaling drives cell invasion and disease progression (Arozarena and Wellbrock, 2017b; Da Forno et al., 2008; Dissanayake et al., 2007; Lai et al., 2012; Liu et al., 2018; O’Connell et al., 2010; O’Connell et al., 2008; Weeraratna et al., 2002).