Elevated expression of WNT5A associates with negative overall survival in melanoma (Da Forno et al., 2008; Luo et al., 2020; Weeraratna et al., 2002); we have observed an inverse correlation for RNF43, which was a positive prognostic factor in melanoma and got silenced as melanoma progressed. This evidence concerns the gene RNF43 and melanoma.