WNT5A and melanoma: Among those mechanisms, WNT5A signaling has a prominent role – WNT5A expression was shown to positively correlate with vemurafenib resistance (Anastas et al., 2014; Prasad et al., 2015; Webster et al., 2015) and WNT5A treatment decreased melanoma cells’ response to the vemurafenib (Anastas et al., 2014; O’Connell et al., 2013).