Alternatively, RNF43/ZNRF3 KO could affect also canonical Wnt/β-catenin pathway that was shown to drive distinct features of melanoma cells than the ones related to the WNT5A-specific events (Arozarena et al., 2011; Arozarena and Wellbrock, 2019; Uka et al., 2020; Webster and Weeraratna, 2013). This evidence concerns the gene ZNRF3 and melanoma.