RNF43 is a β-catenin target gene (Takahashi et al., 2014), which could be a reason for the low RNF43 levels in metastatic melanomas where Wnt/β-catenin signaling is inhibited (Arozarena et al., 2011; Kageshita et al., 2001; Uka et al., 2020). Here, RNF43 is linked to metastatic melanoma.