Interestingly, the in silico analysis of gene expression (Talantov et al., 2005; Xu et al., 2008) showed that RNF43 expression dramatically decreases between benign melanocytic skin nevus and cutaneous melanoma (Figure 4A; Talantov et al., 2005) and further between primary site and metastasis (Xu et al., 2008; Figure 4B). Here, RNF43 is linked to benign melanocytic skin nevus.