We explored and adjusted for relevant variables previously linked to CVD: MMP-2, MMP-9, MMP-14, TIMPS, galectin-3, CRP, metabolic variables, life style variables, depression, and thyroid disease [2, 3, 7–9, 11–14, 16, 17, 19, 21–23, 34–36]. The gene discussed is MMP9; the disease is major depressive disorder.