Introduction of eAldh1a1 in Aldh1a1 neurons restored Aldh1a1 → EGNIS synaptic transmission and rescued the impulsive behaviors (Supplementary Fig. 1d-f), demonstrating that dysfunction of Aldh1a1 → EGNIS synaptic transmission contributes to the impairment of delayed gratification in AD. Here, ALDH1A1 is linked to Alzheimer disease.