By integrating clinic samples, multi-omics study and network pharmacology, our study suggested that both CCQS and QSBS Syndrome of CHD were related with the dysfunction of 5 pathways: glycine, serine and threonine metabolism; biosynthesis of unsaturated fatty acids; linoleic acid metabolism; cholesterol metabolism; and PPAR signaling pathway. This evidence concerns the gene PPARA and coronary artery disorder.