In summary, our study raises the importance of the CTGF interaction network in RA pannus formation, states a new CTGF-combined protein ANXA2, and determines the exact binding site TSP1 domain as well as the function of CTGF-ANXA2 complex on FLS proliferation, migration, and angiogenesis. The gene discussed is ANXA2; the disease is rheumatoid arthritis.