Although we did not observe Syt11 dense stains in the brains of AppNL-F or 3xTg-AD mice at the ages tested (18 and 15 months of age, respectively), a recent proteomics analysis in the cortex of the FADx5 AD mouse model also found Ifit3 and Syt11 among the most upregulated proteins at advanced ages [81]. Here, SYT11 is linked to Alzheimer disease.