Furtherly, we discovered that ITK was positively correlated with CD244 and SOCS1 (a suppressor for cancer) but negatively correlated with SMARCD1. Additionally, deconvolution of the cellular composition of all samples with MCP-counter and CIBERSORT methods validated the immune related analysis and discovered the close correlation between ITK and cytotoxic lymphocytes. The gene discussed is SMARCD1; the disease is cancer.