ITK and hyperinsulinemic hypoglycemia, familial, 4: The numerous evidences of ITK deficiency related human disease have suggested ITK as a promising therapeutic target for various human disease with ITK based molecule inhibitors such as the aminothiazole based ITK inhibitors [20, 21] for suppression of lung inflammation, benzimidazole based ITK inhibitors [22], aminopyrimidine based ITK inhibitor [23], 3-aminopyride-2-ones based ITK inhibitors [24].