After Quinoa intervention, the protein expression of GRP78, eIF2α, and GHOP in the liver tissue of obesity mice was significantly decreased, which indicating that Quinoa can down-regulate the expression of GRP78, eIF2α, and GHOP in the liver tissue of obese mice, inhibiting the ERS, and exerting the anti-obesity effect. The gene discussed is HSPA5; the disease is obesity due to melanocortin 4 receptor deficiency.