We independently evaluated several apoptosis-related genes in AML-E697 cells (Fig. 5E) and found that the expression of genes, which inhibit apoptosis, including AKT, XIAP, ARF1 and BAG5 were significantly downregulated, pro-apoptotic gene BIM was upregulated (Fig. 5F). Here, XIAP is linked to acute myeloid leukemia.