METTL5 and metastatic malignant neoplasm in the lymph nodes: By analyzing the correlation between the expression of METTL5 and clinicopathological parameters in 113 GC patients, we found that the expression of METTL5 protein was closely associated with invasive extent, TNM stage, differentiation degree, growth pattern and perineural invasion other than clinical parameters such as distant metastasis, gender, age, lymph node metastasis, tumor location, maximum diameter and lymphatic/venous invasion (Table 2).