Severe malaria is associated with an increased level of pro-inflammatory cytokines (T helper 1 (Th1) cytokines) such as interleukin (IL)-12, IL-8, and interferon (IFN)-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\upgamma $$\end{document}γ in the affected person which helps to modulate defence against the infection and limit disease progression [59, 82]. The gene discussed is CXCL8; the disease is infection.