The analysis revealed potential pathways between host malaria-associated candidate key protein O00206 (Toll-like receptor 4, TLR4) and pathogen proteins C6KTB7 (Putative E3 ubiquitin-protein ligase protein PFF1365c) and C6KTD2 (Putative histone-lysine N-methyltransferase 1, SET1) that could account for unrestrained parasite growth and severe complications. This evidence concerns the gene UBE2E3 and malaria.