Univariate analysis was performed for the 2917 cases (Table 2), and the clinicopathological parameters influencing the prognosis of patients were race, histologic grade, marital status, age, histology, T stage, tumor radiotherapy and chemotherapy, ER, PR, and HER2, subtypes, primary tumors surgery and surgical procedure (P< 0.05). This evidence concerns the gene ESR1 and neoplasm.