A meta-analysis involving 12 case-control studies for MTR A2756G SNP, seven studies for MTRR A66G polymorphisms (Weiner et al., 2012), and two studies involving Chinese women also found no association between MTR A2756G polymorphism and breast cancer (He et al., 2014; Jiang-Hua et al., 2014). Here, MTR is linked to breast carcinoma.