T7-transcribed, 5’-triphosphorylated leader RNAs from NNS viruses, such as measles, rabies, vesicular stomatitis virus (VSV) or Newcastle disease virus (NDV) were reported to induce the antiviral type I interferon (IFN) system by activating the virus sensor RIG-I [46,47,48]. The gene discussed is RIGI; the disease is measles.