Collectively, a signature for CRC prognosis prediction was developed on the base of 11 autophagy genes, including CX3CL1, ULK3, CDKN2A, NRG1, ATG4B, GAA, RGS19, DDIT3, GRID1, DAPK1 and SERPINA1. This evidence concerns the gene SERPINA1 and colorectal carcinoma.