Herein, a total of 210 autophagy genes were included in this study, and 11 of them, i.e. CX3CL1, ULK3, CDKN2A, NRG1, ATG4B, GAA, RGS19, DDIT3, GRID1, DAPK1 and SERPINA1 were shown to be survival-related in CRC. The gene discussed is SERPINA1; the disease is colorectal carcinoma.