Collectively, a signature for CRC prognosis prediction was developed on the base of 11 autophagy genes, including CX3CL1, ULK3, CDKN2A, NRG1, ATG4B, GAA, RGS19, DDIT3, GRID1, DAPK1 and SERPINA1. Here, ATG4B is linked to colorectal carcinoma.