In keeping with these data, Western blot analysis showed significantly lower levels of PSD-95 in ACx of 3×Tg-AD mice and not in WT exposed to noise compared with their respective age-matched not-exposed animals (Figure 4E and F; n = 4 animals/group; Student’s t-test, AD-NE vs. AD-NN mice p = 0.025). The gene discussed is DLG4; the disease is Alzheimer disease.