Western blot analysis performed on hippocampal extracts from both 3×Tg-AD and WT animals corroborates this result, showing a significantly lower expression of PSD-95 in 3×Tg-AD animals exposed to noise compared with not-exposed animals (Figure 6I and J; n = 4 animals/group; Student’s t-test, AD-NE vs. AD-NN mice, p = 0.028). This evidence concerns the gene DLG4 and Alzheimer disease.