Data of Western blot and ELISA analyses showed significant increases of both TNF-α (~90%) and IL-1β (7.50 ± 1.58 vs. 2.88 ± 0.47 pg/mg) in the hippocampus of 3×Tg-AD mice exposed to noise compared with age-matched not-exposed animals (Figure 8C–E) and no differences between WT-NN vs. WT-NE mice (Figure 8C–E; TNF-α, n = 4 animals/group; Student’s t-test, AD-NE vs. AD-NN mice, p = 0.015; IL-1β, n = 3 animals/group; Student’s t-test, AD-NE vs. AD-NN mice, p = 0.01). The gene discussed is TNF; the disease is Alzheimer disease.