Conversely, no significant modulation of HO-1 expression was found in the hippocampus of 3×Tg-AD mice exposed to noise, compared to age-matched not-exposed animals (Figure 11C and D; n = 4 animals/group; Student’s t-test, p = 0.93), likely due to an impaired ability of the endogenous antioxidant response to counteract oxidative stress and to restore redox balance. Here, HMOX1 is linked to Alzheimer disease.