Among the 479 archived tissue blocks, 56.32% of adjacent non-tumor tissues had high LATS2 expression, compared with only 23.08% of chronic colitis tissues, 15.91% of low-grade intraepithelial neoplasia tissues, 9.09% high-grade intraepithelial neoplasia tissues, and 33.80% of cancerous tissues (Table 1). This evidence concerns the gene LATS2 and intraepithelial neoplasia.