AML patients with high LINC00998 had longer survival time than patients with low LINC00998, and LINC00998 was significantly decreased in human AML (AUC = 0.8075) and recurrent tissues (AUC = 0.8128), suggesting that LINC00998 is tissue-specifically expressed in AML and can be used as a promising biomarker for AML diagnosis, prognosis and relapse. The gene discussed is SMIM30; the disease is acute myeloid leukemia.