In addition, some lncRNAs have been proven to be a key regulator in AML progression, such as ANRIL [28], HOTTIP [29], SATB1-AS1 [30], etc. Further studies are needed to clarify whether these lncRNAs interact with each other to form a huge regulatory network that accurately controls the occurrence and development of AML, and whether several combinations of these lncRNAs can better diagnose and predict AML. Here, HOTTIP is linked to acute myeloid leukemia.