The aim of the research was to determine the expression of miR-355-5p expression in the plasma samples of childhood asthma, to investigate the effects of miR-335-5p on inflammation, fibrosis, and autophagy on ASMC, to assess the association between MiR-335-5p and ATG5 and to determine the effects of ATG5 Overexpressing on miR-335-5p on ASMC inflammatory response, fibrosis, and autophagy. This evidence concerns the gene ATG5 and asthma.