In the late stage of NAFLD, autophagy was weakened due to the degradation of autophagy-related gene Atg7, the change of lipid composition of autophagy membrane and lysosome membrane, the weakening of autophagy-lysosomal proteolysis function, hyperinsulinemia, and the increase of intracellular calcium level in hepatocytes, which aggravated NAFLD [23]. The gene discussed is ATG7; the disease is Hyperinsulinemia.