Hepatic steatosis can inhibit liver regeneration by regulating the endoplasmic reticulum stress signal pathway, increasing the expression of transforming growth factor B1, JAK/STAT signal pathway, ERK/MAPK signal pathway, and reduced ATP synthesis, and can also promote liver regeneration through a high expression of proliferation and anti-apoptotic molecules. This evidence concerns the gene SOAT1 and Hepatic steatosis.