Platelet cell membranes gained interest indesigning CMC mimicsfor targeting CTCs due to the effective interaction between P-selectinand CD44 receptors on platelets and tumor cells.338 According to these reports, platelet membrane-coated mimicscaptured and killed CTCs in blood and lymph nodes and inhibited breastcancer metastasis effectively.87,119 Further, TNF-relatedapoptosis-inducing ligand (TRAIL) modified platelet membrane-coatedtemplates also eliminated CTCs effectively. Here, TNFSF10 is linked to neoplasm.