However, based on the previous findings,10, 17, 18, 33, 39, 47, 50, 51 some factors or metabolic status such as type 2 diabetes mellitus, impaired glucose tolerance, metabolic syndrome, PCOS, BMI, fat mass or adipose tissue, fasting insulin, and IR, serum triglycerides, and blood pressure may influence serum and FF chemerin levels or ovarian chemerin mRNA expression, the data were weak or low for other variables (subcutaneous and omental adipose tissue chemerin mRNA expression or protein expression). This evidence concerns the gene INS and polycystic ovary syndrome.