miR-34a expression can also be regulated by histone modifications [70, 71], for instance, Wang and collaborators reported that the long non-coding RNA Lnc34a, that modulates colon cancer stem cells self-renewal, is upregulated in late-stage colorectal cancer where it can epigenetically silence miR-34a by recruiting DNA (cytosine-5)-methyltransferase 3A (DNMT3A) and Histone deacetylase 1 (HDAC1) that respectively and simultaneously methylate and deacetylate this miRNA promoter [72]. Here, DNMT3A is linked to malignant colon neoplasm.