IFIH1 and infection: Near-baseline levels of IFN-α were seen in bone marrow-derived dendritic cells (BMDCs) from MDA5-deficient (Ifih1-/-) mice following infection with an acute strain of MNV (CW3) compared to the wild-type, with a significant increase in viral titres seen in the spleen, mesenteric lymph nodes (MLN) and proximal intestines.