To determine whether ASOs can be used to modulate mitochondrial dynamics, we administered a panel of ASOs targeting mitochondrial fusion and fission factors (Mfn1, Mfn2, Drp1, Fis1, Mff, Mief1, Mief2) to MHT (mouse hepatocellular carcinoma) cells in culture [28]. The gene discussed is FIS1; the disease is hepatocellular carcinoma.