The skin mass biopsy revealed DLBCL, positive for CD20, Ki67 (60–70%+), CD10, Bcl‐2, Bcl‐6, MYC and negative for CD3, CD56, CD34, CD123, CD21, MUM‐1, TdT and CD5. The gene discussed is BCL2; the disease is diffuse large B-cell lymphoma.