This may be conservative as we found literature evidence that the genes in the top perturbed gene pair of the visual phototransduction control pathway, METAP2‐FNTA, play roles in oncogenic progression in rhabdomyosarcoma (Nielsen et al, 2012) and pancreatic endocrine tumors (Larghi et al, 2012), respectively. This evidence concerns the gene METAP2 and pancreatic neuroendocrine tumor.