We also measured perforin (PRF1) and granzyme A (GZMA) gene expression as representations of cytolytic activity (CYT) in tumors (Rooney et al, 2015) and found that CYT was inversely correlated with tumor stages across all cancer types (n = 6,458, 25 tumor types) (Fig 2B). The gene discussed is GZMA; the disease is neoplasm.