CD274 and neoplasm: Of interest RIDD also degrades miRNAs (Upton et al, 2012; Wang et al, 2018) including miR‐34a which negatively regulates PD‐L1 expression (Wang et al, 2015), induces cellular senescence by modulating telomerase activity (Xu et al, 2015), and inhibits adrenergic transdifferentiation of tumor‐associated sensory nerves in a p53‐dependent manner (Amit et al, 2020).