It is possible that the homozygous genotype (CC) results in the decrease in TGFβ cytokine production for malaria eradication [20], whereas the heterozygous genotype (CT) results in the increase in TGFβ cytokine production and high parasite density, thereby, perhaps, enhancing the risk of severe malaria [21]. The gene discussed is TGFB1; the disease is malaria.