Specifically, V600E|V600M BRAF mutated melanomas downregulated let-7b-3p|0|−1(+1U), miR-100-5p|0|0(+1U), miR-125b-5p|0|0, miR-221-3p|0|−1, and upregulated let-7a-5p|+1|−2, miR-1247-5p|0|−1, miR-219a-1-3p|0|0 compared to V600E BRAF mutated melanomas. This evidence concerns the gene BRAF and melanoma.