Melanoma risk is increased in people harboring specific germline genetic alterations [3], which include mutations in Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) gene [4,5], Cyclin Dependent Kinase 4 (CDK4), Telomerase Reverse Transcriptase (TERT), Microphthalmia-associated transcription (MITF), BRCA1-associated protein-1 (BAP1), and Protection of telomeres 1 (POT1) [6]. The gene discussed is CDKN2A; the disease is melanoma.