The permeability-glycoprotein; ABCB1 low protein levels in STZ-rats are in concert with a previous report, in which hyperglycemia inhibited Pgp expression [54], thus explaining the provoked STZ toxicity on both pancreatic and renal cells, due to inefficient foreign-substances pumping out of cells [24]. This evidence concerns the gene ABCB1 and Hyperglycemia.