Univariate analysis using the chi-square test revealed that MC1R expression was significantly correlated with P53 status (p = 0.030), MLH1 status (p = 0.048), PMS2 status (p = 0.041), and MS status (p = 0.034) in the clinical CRC samples that we examined. The gene discussed is PMS2; the disease is colorectal carcinoma.