MC1R and colorectal carcinoma: The overall survival of 15 MC1R altered group patients and 1476 MC1R unaltered group patients in the Kaplan–Meier Plotter Database from cBioPortal (www.cbioportal.org, accessed on 5 June 2021) showed that the MC1R altered group was associated with an unfavorable prognosis in CRC patients (Figure 6K).