INS and type 2 diabetes mellitus: In our separate in vivo experiment, however, oral administration of daidzein, an isoflavone, to T2D model db/db mice with high serum insulin levels and strong insulin resistance was found to increase the activated (=phosphorylated) AMPK (p-AMPK) in gastrocnemius muscle tissues, and to suppress the increase in blood glucose levels in vivo [30].