Interestingly, no study on the association between VDR gene variants with BMD or osteoporosis risk was reported in Arab ethnicity; hence the rationale of this study was to investigate the influence of three VDR gene variants (rs7975232, rs1544410, and rs731236) on BMD and susceptibility to osteoporosis in Saudi postmenopausal women. This evidence concerns the gene VDR and osteoporosis.