Therefore, the concept of “phenotypic plasticity” of melanocyte cells has been developed, as it has been demonstrated that the microenvironment where melanocytes operate is able to bi-directionally influence the following phenotype: in particular, the study of melanocytes has been deepened, inducing the transcription factor (MITF) whose expression (also detectable in immunohistochemistry) was correlated with a different biological behavior of melanoma cells. This evidence concerns the gene MITF and melanoma.