Additionally, multiple angiogenic and antiapoptotic cytokines, including growth factors, such as insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), and hepatocyte growth factor (HGF), were shown to be secreted by AD-MSCs, promoting tissue regeneration and reducing tissue damage [14,15,16]. This evidence concerns the gene IGF1 and Alzheimer disease.