Recently, lncRNAs are also found to be involved in CSC progression or the CSC-like traits of cancer cells, for example, lncRNA LUCAT1 has been found to be related to the metastasis and TNM staging and promote the self-renewal of breast CSCs [7]; LncRNA Sox2OT is shown to promote the CSC-like traits of bladder cancer cells by sponging miR-200 c and thus positively regulating Sox2 expression [8]; And lncRNA NEAT1 confers cancer stemness and sensitizes cells to chemotherapy in triple-negative breast cancer (TNBC) [9]. The gene discussed is SOX2; the disease is cancer.