Among these items, GO:0043406 positive regulation of MAP kinase activity, hsa04141 protein processing in the endoplasmic reticulum, hsa04926 relaxin signalling pathway, hsa04919 thyroid hormone signalling pathway, hsa04010 MAPK signalling pathway and hsa05010 Alzheimer's disease was related to ICM. The gene discussed is TG; the disease is early-onset autosomal dominant Alzheimer disease.