We performed in silico analysis of our colonic gene microarray dataset (99 CD, 129 UC and 50 non-IBD controls; available at Gene Expression Omnibus (http://www.ncbi.nlm.nih.gov/geo/ [accessed September 2020] accession: GSE11223 and GSE20881) [5] to demonstrate ACE2 gene expression in whole gut mucosal biopsies is significantly higher in the ileum compared with colon, with the reverse pattern seen for TMPRSS2 (Fig. 1B). The gene discussed is ACE2; the disease is inflammatory bowel disease.