The results showed that the potential targets of Angelica and Astragalus in the treatment of male infertility include TP53 (tumor protein P53), mapk1 (mitogen-activated protein kinase 1), IL-6 (interleukin-6 receptor), ANXA1 (annexin-A1), EGF (epidermal growth factor), and EGFR (epidermal growth factor receptor). Here, EGF is linked to male infertility.